L-Leucine, L-leucyl-, methyl ester, monohydrochloride

L-Leucine, L-leucyl-, methyl ester, monohydrochloride - Names and Identifiers

Name	L-Leucyl-L-Leucine methyl ester (hydrochloride)
Synonyms	Leu-Leu-ome hydrochloride H-Leu-leu-OMe hydrochloride L-Leucyl-L-Leucine methyl ester L-Leucyl-L-Leucine methyl ester (hydrochloride) L-Leucine, L-leucyl-, methyl ester, monohydrochloride methyl (2S)-2-[(2S)-2-amino-4-methylpentanamido]-4-methylpentanoate hydrochloride
CAS	6491-83-4

L-Leucine, L-leucyl-, methyl ester, monohydrochloride - Physico-chemical Properties

Molecular Formula	C13H27ClN2O3
Molar Mass	294.81808
Melting Point	177-181°C
Solubility	DMSO (Slightly), Water (Slightly)
Appearance	Solid
Color	White to Off-White
Storage Condition	Hygroscopic, Refrigerator, under inert atmosphere
Stability	Hygroscopic
In vitro study	L-Leucyl-L-Leucine methyl ester (1 mM; 0.5-2 h) enhances LRRK2-mediated Rab10 and Rab12 phosphorylation in MEFs and A549 cells. L-Leucyl-L-Leucine methyl ester (10-250 μM; 15 min) is converted to a CCI 3 COOH-insoluble product by CD4 - lymphocytes.

L-Leucine, L-leucyl-, methyl ester, monohydrochloride - References

biological activity

L-Leucyl-L-Leucine methyl ester (LLOMe) hydrochloride, a dipeptide condensation product of L-leucine methyl ester produced by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methylester hydrochloride can also induce lysosomal pathway stress.

Last Update：2024-04-09 20:52:54